Applied Therapeutics’ muted response to a clinical hold speaks volumes

first_img What’s included? STAT+ is STAT’s premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond. By Adam Feuerstein Aug. 17, 2020 Reprints [email protected] Tags biotechnologyFDASTAT+ Adam Feuerstein GET STARTED What is it? Senior Writer, Biotech Adam is STAT’s national biotech columnist, reporting on the intersection of biotech and Wall Street. He’s also a co-host of “The Readout LOUD” podcast. Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr. Unlock this article by subscribing to STAT+ and enjoy your first 30 days free! GET STARTED About the Author Reprints Applied Therapeutics’ muted response to a clinical hold speaks volumes Log In | Learn More How a company communicates with investors can be just as meaningful as what it communicates.Take Applied Therapeutics, which used an SEC filing on Monday morning to disclose that the Food and Drug Administration placed a partial hold on one of its important clinical trials, involving its lead drug and children with a rare metabolic disease. @adamfeuerstein Adam’s Take last_img read more


Florida lawyers report video conferencing challenges

first_img Seven months after COVID-19 made remote legal proceedings the “new normal,” Florida Bar members report many challenges associated with various aspects of video conferencing, a recent survey shows.Some 2,003 Bar members responded to a September 18 survey that the Board Technology Committee conducted to help design projects that are intended to make digital life easier for Florida lawyers.Florida courts relied mostly on remote technology to dispose of 2.5 million cases this fiscal year, but the survey suggests that opposition to its use, while limited, may never completely disappear.One respondent considers the use of video conferencing “ineffective assistance of counsel.”“I will not and cannot use Zoom for hearings requiring testimony on an issue in dispute or a hearing that requires a factual finding by the court,” the respondent wrote. “Despite what others say, there is a vital constitutional confrontation issue for any hearing using a video forum.”But a majority of respondents, 73%, reported video conferencing with clients in the last three months. Another 67% cited Zoom as their primary platform for “court-related events.”During the past three months, 66% of respondents reported using video conferencing to meet with clients and 59% for meeting with other attorneys.Another 46% reported using video conferencing for mediations, 44% for depositions, and 20% for trials.When asked, “Have you experienced any difficulties while utilizing your primary video conferencing platform,” 61% replied “No.”Thirty-seven percent answered “yes.”Of the more than 900 respondents who reported difficulties, 382 cited “internet connectivity/bandwidth” the most frequently cited issue.The second most frequent, “audio/sound,” was cited by 165 respondents. They were followed by “user error/lack of training,” “minor technological problems/glitches,” and “use of exhibits/admitting evidence.”Lack of bandwidth and connectivity issues have been a frequent source of frustration, according to the survey.“A video deposition could not be completed due to the deponent residing in an area with poor Internet access,” wrote one respondent. “Had to reschedule and he had to travel to a court reporter’s facility to complete the deposition.”User error problems are more likely to crop up when more than one party is participating, according to one respondent.“Coordinating use of video conferencing tools with all parties involved is still a challenge,” the respondent wrote. “Many users are still figuring out the technology and the etiquette.”Difficulty admitting evidence is another frequent challenge, according to the survey.“When the exhibits are shown on the screen, they can be difficult to read,” according to one respondent. “Producing exhibits in advance helps, but at the same time, I’d rather not broadcast to the other side exactly the exhibits that I will be questioning the witness about.”“For complex medical litigation, it can be difficult to anticipate which of the voluminous medical records or other materials are critical to have prepared for use and then display,” another respondent wrote.Survey respondents cited variations between circuits, and sometimes within circuits, in the types of video conferencing platforms being used and procedures for such things as admitting evidence. The committee expects soon to release a set of guidelines or best practices that should address the issue.Survey respondents also cited the need for instructional material and CLE to help lawyers become more familiar with video conferencing. The Standing Committee on Technology has a host of tutorials already in the works.Board Technology Committee Chair Jay Kim told the Board of Governors at an October 23 meeting that the committee also plans to approach video conferencing providers to ask for lawyer friendly features.The survey should provide the committee with a wealth of ideas.Nearly 600 Bar members submitted suggestions when asked, “What specific changes to your primary video conferencing platform would you suggest in order to optimize its use in legal proceedings?”Seventy suggestions focused on “Share exhibits/Screen,” according to the survey.Several respondents suggested “multiple cameras” to expand visibility of the proceedings.“It is impossible to verify that the deponent is not receiving assistance from counsel and/or other written means via electronic or in-person writing,” one respondent wrote.“There should be multiple cameras,” another wrote. “There should be a camera of the entire room where the witness is located, and there should be another camera focused on the witness.”Several respondents asked for a “knock” feature to let participants know when someone is joining the proceedings.“There should be an audible announcement when people come and go to let the other people know they are there,” one respondent wrote.“A doorbell function in Zoom to announce coming in and out of rooms,” wrote another.The survey was emailed to members of the Real Property, Probate & Trust Law, Trial Lawyers, Business Law, Family Law, Criminal Law, and Appellate Practice sections. Florida lawyers report video conferencing challenges Nov 02, 2020 By Jim Ash Senior Editor Top Storieslast_img read more


Two Savannah cops fired for use of excessive force during arrest

first_imgkali9/iStockBy IVAN PEREIRA, ABC News(SAVANNAH, Ga.) — The Savannah Police Department announced Wednesday that it terminated two of its officers following a three-month investigation into excessive force used in an arrest.District Attorney Meg Heap told reporters at a news conference that she will call for a grand jury in September to look into the April incident involving Corporal Daniel Kang and Sergeant Octavio Arango. Heap, the police officers and Mayor Van R. Johnson did not disclose specific details about the incident — which was caught on body cameras — but they did say excessive force was used during a warrant sweep on a suspect who, ultimately, was misidentified.“Based on my review of the internal investigation and the video, I believe that the conduct of the two members of the Savannah Police Department during this particular incident was totally unacceptable and egregious behavior on their part,” Johnson said at the news conference.Following the incident, the officers notified their supervisors about the use of force during the arrest, the Savannah Police Department said. The supervisors alerted internal affairs after reviewing the details of the incident and body camera footage, and the officers were put on administrative leave.In July, internal affairs terminated the officers for “conduct unbecoming of an officer,” and other charges. Savannah Police Department Chief Roy Minter presented the evidence and body camera footage to the Savannah CARES Task Force, which was created last month by the mayor to review current use of force policies and internal affairs data in the police department.“Last Friday, the CARES Task Force gathered in person and they reviewed the body cam video, and they made a recommendation to the chief that the actions of the officers warranted a referral to the district attorney’s office,” the mayor said.Arango had been with the department for approximately 15 years and Kang for eight, according to police. Attorney information for the officers wasn’t immediately available.“We have worked hard to build a rapport with our community and want to strengthen that trust,” Minter said in a statement.Copyright © 2020, ABC Audio. All rights reserved.last_img read more


Overland Park council members criticize city administration for furloughing part-time employees during pandemic

first_imgOverland Park has furloughed 200 part-time employees and delayed raises for two months in an attempt to slash spending during the pandemic. But the actions taken last week by City Manager Bill Ebel have drawn criticism from three city council members who say they are unnecessarily harsh on working people and first responders who depend on those raises.The council members – Faris Farassati, Gina Burke and Scott Hamblin – also said that even though Ebel has the authority to make those decisions without a council vote, the rest of the council should have been informed and consulted.City officials confirmed the actions Tuesday, saying the part-time employees worked at the city’s two community centers and will be called back when it’s once again safe to reopen the buildings. The Matt Ross and Tomahawk Ridge community centers closed to the public March 15 as the county began stringent social distancing measure to reduce spread of COVID-19. About half of the furloughed part-timers agreed to stay on for another week to complete cleaning and maintenance work.Those who worked during the last 10 weeks will still be paid for the two weeks from March 22 through April 4 in amounts based on their average weekly hours, according to a city summary of the furlough. The affected employees worked in a variety of positions such as fitness class instructors, front desk attendants and babysitting.The city will try to find alternative work for as many furloughed employees as possible, said spokesman Sean Reilly. Those jobs might include planting and outdoor work at the city’s parks, the Arboretum, Deanna Rose Children’s Farmstead and soccer complex, for example.But Farassati said the city could have kept those workers by spending some of its reserve fund. The $40,000 every two-week pay period cost to the city should not be enough to break the bank, especially this early in what could be a long fight against COVID-19, he said. After the crisis is over, those workers could do extra to make up for the paid weeks off, he said.He and Hamblin say they are also concerned about the delay in pay raises. Performance evaluations are typically done by the end of March, but this year that deadline has been extended to the end of April, Reilly said. As a result the city will hold off on scheduled pay increases for 60 days.Hamblin said he’d first heard about the raise delay from first responders concerned about missing money they’d counted on. Some told him they only heard about the delay two days before the raises were supposed to go into effect.No dollar figures were available on how much that action would save the city. But Hamblin and Farassati said first responders in particular shouldn’t have to deal with a loss of expected pay.“They’re out there facing this thing on the front lines,” Hamblin said. “They’re still working their regular jobs, risking bringing (COVID-19) home.”Hamblin suggested the first responders should be exempt from the raise delay, or perhaps get some kind of hazard pay. “They should be getting paid more, not less,” he said.City bracing for sharp hit to sales tax revenueReilly said the pay actions were part of an extensive effort to find ways to conserve in the face of what is expected to be severely declining tax revenue. The closure of stores and Oak Park Mall are bound to have a big impact on the rest of this year’s budget, he said, adding that city officials will also be taking a hard look at construction projects scheduled for this year that could be put off.But in a letter protesting the measures, Burke, Hamblin and Farassati said $50 million in the reserve fund should be able to take care of workers for a short time. “The role of government during such a time of need is not to create unemployment for the staff that have faithfully served the city for years,” said their letter, which also asked Ebel to reverse the action.Farassati called out the tax incentives to developers as a possible driver of the decision. He said such things as tax increment financing, which uses future property tax revenue brought about by development improvements to pay some of the developers costs, has eaten away at Overland Park’s financial stability. He also asked whether some public financing plans could be put on hold instead of cutting paychecks.He and Hamblin said they were reluctant to bring their concerns forward in a time of national crisis. “This crossed a line,” Farassati said.Mayor Carl Gerlach said he did not sign off on the measures but supports them just the same. The city council approves the budget each year, but Ebel is in charge of making changes within it to be sure the city doesn’t overspend. Tax incentive packages are heavily regulated contracts, and putting them off open the city to legal action, he said.The problem is right now no one knows how long the stay-home orders will last or how big an impact COVID-19 will have, Gerlach said.“It’s a critical time and we’re just trying to make decisions based on as much as we know.”He added that he was disappointed in the letter from Hamblin, Burke and Farassati, who has announced he is running for mayor. People need to come together to find solutions, Gerlach said.“During crisis pandemics like we’re n right now people aren’t looking for political campaign rhetoric,” Gerlach said. “They’re looking for leadership.” Taking action on the budget now will help the city maintain a long run of financial stability and a top quality of life, he said.last_img read more


Three elected to the Board of Governors

first_imgThree elected to the Board of Governors Three elected to the Board of Governors One incumbent and two newcomers have been elected to The Florida Bar’s Board of Governors.In the three board races decided in the March balloting:• Incumbent Scott R. McMillen turned back a challenge from Patrick T. Christiansen by a vote of 786 to 562 in the Ninth Circuit, Seat 3, race.• O. John Alpizar defeated Roshani Mala Gunewardene 595 to 101 to represent the 18th Circuit, Seat 1 race.• Marcy L. Shaw, with 404 votes, won a four-way race against Luis E. Insignares, 231, Matthew Alan Linde, 105, and Tracey Dew-rell, 18, in the 20th Circuit, Seat 2, race.The 20th Circuit contest was to fill an unexpired term and Shaw begins service immediately. McMillen and Alpizar will be sworn in for full terms at the Bar Annual Convention in June.In balloting for the Young Lawyers Division Board of Governors:• Christian P. George defeated Michael E. Lockamy 158 to 71 in the YLD Fourth Circuit, Seat 1, race.• Andrew B. Pickett bested Vera L. June 113 to 28 in the YLD 18th Circuit, Seat 1, race.• Ben Gibson and Jennifer Shoaf Richardson will face each other on an April runoff ballot for Seat 1 in the Second Circuit. Gibson received 111 votes, or 49.78 percent, and Richardson 85 in the three-way race. They were followed by Joshua D. Zelman with 27 votes.Ballots for the runoff will be mailed around April 1. They must be returned to the Bar’s election company no later than 11:59 p.m. on April 23. The mailed ballots will contain instructions for voting with the enclosed paper ballot or for casting a vote online. See the candidates’ platform statements .In all, 49 percent of the votes were cast electronically and 51 percent were returned by mail.center_img April 1, 2012 Regular Newslast_img read more


Focus on Yourself to Alleviate Social Pain

first_imgScientific American Mind: Many people who suffer the pain, depression and negative health effects associated with social anxiety or loneliness do not respond to common therapy tactics or drugs. Two new studies offer hope from an unlikely source: rather than focusing on your relationships with others, turn inward for relief.Mindfulness meditation—which has been around for well over 2,000 years—has many forms, but an extensive body of research supports the effectiveness of one training program in particular. Mindfulness-Based Stress Reduction (MBSR) is an eight-week program developed in 1979 by a U.S. physician. Initially created to help patients suffering from chronic pain, the program has been found to reduce symptoms of stress, depression and anxiety, even among people with cancer and HIV.Read the whole story: Scientific American Mind More of our Members in the Media >last_img read more


CPA appoints Henshaw

first_imgHenshaw joins CPA from Maine Port Authority, where he served as executive director. He currently serves as the chair of the board of advisors of the International Association of Maritime and Port Executives. CPA said that Henshaw will be responsible for fostering the economic development of Connecticut’s maritime economy and will oversee the development and growth of its small harbours and three deepwater ports.www.ctportauthority.comlast_img


Summer League Recap: Cavs Fall to Lakers

first_img Matt Medley is co-editor at NEO Sports Insiders, covers the Cleveland Cavaliers, Cleveland Indians and high school sports in Northeast Ohio.Follow @MedleyHoops on Twitter for live updates from games. Related Topics We’re not going to go too in-depth with this recap because frankly, there wasn’t much positive to write home about from the Cavaliers standpoint.It was a great night for Lakers fans, who have one of the most talented Summer League rosters – even without last year’s No. 2 pick, Brandon Ingram.Lonzo’s Triple-DoubleLonzo Ball put up 12 points, 12 assists and 10 rebounds. He’s posted 11 assists or more in three-straight games.He was wearing Adidas in case you were wondering.Kyle Kuzma Lights It Up AgainThe No. 27 pick is looking like he could be one of the best finds of this year’s draft. He scored 31 on Saturday night and was in a groove on Thursday, scoring 20 points, knocking down 4-of-8 three-pointers.The stretch four looks like he’s going to benefit tremendously from Ball’s great playmaking ability and the Lakers have a promising core in the making with Ingram progressing as well.About Those Cavs….. 5 Quick Thoughts1. The team looked much worse without Brandon Paul.There’s somewhat of a contingency of Cavs fans and writers (myself included) who were upset to see Paul, Cleveland’s leading scorer in Summer League play, get swiped right under the Cavaliers’ noses by the San Antonio Spurs.He might turn into a productive NBA player. He might be a G-Leaguer and nothing more. But my money is on Gregg Popovich and the San Antonio Spurs having better player evaluation than Cleveland’s fraction of a front office, which seems to think adding guys whose careers are trending downwards is a better strategy to keep up with the athleticism of the Golden State Warriors than going with younger players with potential and energy.The offense was lethargic and a lot of it consisted of Kay Felder driving and pulling up for reckless contested jumpers.2. 26 Field Goal Attempts for KayFelder scored a game-high 25 points, going 11-for-26 from the field.Cleveland didn’t have much of an offense in rhythm and not many players were stepping up in Paul’s absence, so Felder took a big chunk of the shots.He started off 2-for-9 in the first quarter, found a little bit of a groove in the second and third quarter, and went scoreless in the fourth.Altogether, it was another night of some flashy playmaking, a few dazzling moves and finishes, but mostly, a frustrating night to watch for the second-year point guard.Most players are supposed to look like they’ve grown by leaps and bounds after their first year in the league. It’s tough to tell how much Felder’s game has evolved since last summer, as he’s been in a new role of facilitating the offense, but he certainly hasn’t been more efficient than last summer and he doesn’t look any more polished than some of the rookies and non-NBA candidates on other rosters.He’s still very raw, athletic and quick, but overall, he hasn’t shown great decision-making and his defense continues to be a liability, even against Summer League players (not just Ball).3. Tavares UnderwhelmingI’m not quite sure what the problem has been with Tavares, but he hasn’t been “getting after it,” or fighting for as many rebounds as you’d like to see out of the team’s true backup center.At 7-foot-3, he’s only grabbed 25 rebounds in four games, averaging roughly 17 minutes per game. If you take away Friday’s Summer League opener, he has only 13 rebounds in the last three contests.He’s played just 30 minutes total in the last two games (15 in each). Perhaps he’s being used conservatively because he’s coming back from a fractured bone in his hand, which would explain his lack of aggression and production, but aside from his five blocks on Monday, there hasn’t been a lot to get excited over when it comes to the big man.At this point, my guess is we’ll have to re-evaluate his play in preseason when he’s had more than six months to recover from his injury.4. Pointer’s PositivesOne of the rays of hope in this game (and in the last game) was Sir’Dominic Pointer. His athleticism, hustle and tenacity stand out.He’s thrown down a few vicious dunks in the last two games. It makes you wonder why he didn’t get a shot in the first two. The 6-foot-6 forward scored 11 points on 5-of-8 shooting and grabbed seven rebounds.In these two games, he’s shot 11-for-16 with 24 points and 12 rebounds. He’s been one of Cleveland’s most efficient players in Las Vegas and has the type of body the Cavs would be looking for to match up with versatile wings.He’s far from a shoe-in to get a two-way contract, but I still wouldn’t rule it out, as he’s really made a positive impact when given the chance.5. Williams/Cassell Jr./Gill/Prather – Ability is There, Fit is NotCleveland’s Summer League squad has several players who have shown promise, composure and solid two-way ability in these four games.T.J. Williams, who started off on a roll and cooled off the last two games is one of those guys. It’s hard to explain his poor shooting in the last two games, as he went 2-for-16 from the field against the Lakers, but he still managed to get to the free throw line and knock down 6-of-6 attempts. He went 9-for-12 from the field in the first two games. His scrappy play on defense, hustle and court vision are all positives and I won’t be surprised to hear his name called in the G League for another team this season.Sam Cassell Jr. put up seven points and made a couple deep shots from just inside the three-point line. He’s made good decisions with the ball in his hands and hasn’t been burned on defense much, if at all in these four games.Anthony Gill has been one of the more athletic 6-foot-8 players on the court in all four games he’s played with the Cavs. He grabbed double-digit rebounds for the third time out of that four-game stretch on Thursday. Word is (according to David Pick), he has an overseas deal coming his way again.Casey Prather made 5-of-11 shots and scored 10 points, grabbing seven rebounds. There’s a lot to like about his game. He plays smooth, under control and is in the right place at the right time. The 6-foot-6 forward has the tools and the basketball IQ to be a solid contributor at Summer League play for sure, but it’s unclear if he’d be able to make a jump into NBA action any time soon. He’ll probably make a good chunk of change overseas and I could see a place for him on a two-way contract, just probably not with the Cavs right now, especially given their “win-now” mode.That’s the problem when it comes to so many of these Summer League players trying out for the Cavs. Cleveland is not in a position to throw these guys into the fire and see how they handle it. Even Felder or Tavares at this point. With the focus clearly set on NBA Championship or bust, Cleveland is not the type of place to give Gill, Prather or Williams meaningful minutes to learn under pressure.There is enough ability in some of these guys that it’d be interesting to see how they adjust to NBA basketball, but the fit is just not there with this franchise.I’d like to see a few of them latch on with other NBA teams and get a shot.Cavs are back at it on Friday night at 10:30 pm ET, taking on the Toronto Raptors on NBA TV.They’ll look to finish Summer League play with a record of 4-1.center_img Matt Medleylast_img read more


Hockey News 2023 Men’s Hockey World Cup To Be Hosted By Odisha

first_imgNew Delhi : After successfully hosting FIH Men’s Hockey World Cup in the year 2018, Odisha gets another opportunity to host huge event four years later in 2023.Earlier, International Hockey Federation (FIH) announced that India has won the rights to host the 2023 event leaving behind Belgium and Malaysia.Chief Minister of Odisha, Naveen Patnaik on Wednesday announced that the match of the World Cup to be played in Bhubaneswar and Rourkela. “We hosted the 2018 World Cup and I would like to announce that the 2023 Hockey World Cup will again be held in Bhubaneswar and Rourkela. Are you happy. I am happy,” Patnaik said, while addressing the crowd at the Kalinga Stadium in a brief ceremony.The ceremony was also attended by International Hockey Federation and Indian Olympic Association president Narinder Batra, Hockey India president Mohd. Mushtaque Ahmed, Odisha Sports Minister Tusharkanti Behera, besides other dignitaries.Bhubaneswar’s Kalinga Stadium will host the game’s showpiece tournament for the second consecutive time after successfully conducting the event in 2018, which was won by Belgium.The mega event is to be held from January 13-29, 2023 while the women’s event to be held from July 1-17, 2022. The women’s World Cup would be hosted jointly by Spain and the Netherlands — also the first time the event would be held across multiple countries — in 2022.The FIH had proposed two windows for both events — in 2022 and 2023. The other bidders for the women’s event were Germany (in 2022), Malaysia and New Zealand (in 2023). For all the Latest Sports News News, Hockey News News, Download News Nation Android and iOS Mobile Apps.last_img read more


Watch the show by Grigor Dimitrov (Video)

first_imgAnother video with selected attractive hits of has been released on social networks Grigor Dimitrov. This time, performances are preferred, from which “your jaw will fall”.After spending the coronavirus, Dimitrov is already training in Monte Carlo, where he lives.last_img


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